Genetic changes are the hallmark of certain cancers. Fluorescent In-Situ Hybridization (FISH) is generally used to detect those changes. Chromogenic In-Situ Hybridization (CISH) is emerging as a practical and valid alternative to FISH in testing for gene alterations. These two techniques differ in the way the final detection is made: in FISH, fluorescent light is detected by a special type of microscope, while in CISH, only a bright field microscope is required. In many cases FISH is still the preferred method for its superior sensitivity and quality of microscopic images.
